Chapter title |
Dipeptidyl Peptidase IV in Inflammatory CNS Disease
|
---|---|
Chapter number | 16 |
Book title |
Cellular Peptidases in Immune Functions and Diseases 2
|
Published in |
Advances in experimental medicine and biology, January 2000
|
DOI | 10.1007/0-306-46826-3_16 |
Pubmed ID | |
Book ISBNs |
978-0-306-46383-9, 978-0-306-46826-1
|
Authors |
Andreas Steinbrecher, Dirk Reinhold, Laura Quigley, Ameer Gado, Nancy Tresser, Leonid Izikson, Ilona Born, Jürgen Faust, Klaus Neubert, Roland Martin, Siegfried Ansorge, Stefan Brocke |
Abstract |
Current pathogenic concepts of inflammatory demyelinating disorders such as multiple sclerosis (MS) are based on the hypothesis that a T cell-mediated autoimmune response is involved in the disease process. One of the primary goals in the in the development of immunotherapies for autoimmune diseases has been to achieve inactivation of disease-inducing lymphocytes either by direct inhibition or suppression through regulatory cells and/or cytokines. The CD26 antigen is identical with the cell surface ectopeptidase dipeptidyl peptidase IV (DP IV, EC 3.4.14.5) which is involved in regulating T cell activation and growth. Activated T cells, including those specific for myelin antigens, express high levels of CD26/DP IV. In vitro, reversible DP IV inhibitors suppress T cell proliferation and pro-inflammatory cytokine production in response to myelin antigens. Further studies will evaluate the role of DP IV inhibition in T cell-mediated inflammatory disease of the central nervous system. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 8% |
Belgium | 1 | 8% |
Unknown | 10 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 25% |
Professor > Associate Professor | 2 | 17% |
Professor | 2 | 17% |
Lecturer | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Other | 2 | 17% |
Unknown | 1 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 17% |
Medicine and Dentistry | 2 | 17% |
Neuroscience | 2 | 17% |
Psychology | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |