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Notch Signaling in Embryology and Cancer

Overview of attention for book
Cover of 'Notch Signaling in Embryology and Cancer'

Table of Contents

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    Book Overview
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    Chapter 1 The Molecular Basis of Notch Signaling: A Brief Overview
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    Chapter 2 The Role of Adams in Notch Signaling
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    Chapter 3 Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O -Fucosylation Of Notch
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    Chapter 4 Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages
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    Chapter 5 NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex
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    Chapter 6 Notch Signaling and Development of the Hematopoietic System
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    Chapter 7 Notch signaling in lung development and disease.
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    Chapter 8 The Role of Notch Signaling in Kidney Development and Disease
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    Chapter 9 Notch Signaling and the Developing Skeleton
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    Chapter 10 Notch signaling and the developing skin epidermis.
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    Chapter 11 Notch Signaling and the Developing Hair Follicle
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    Chapter 12 Notch Signaling and the Developing Inner Ear
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    Chapter 13 Notch signaling in cancer stem cells.
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    Chapter 14 Notch Signaling Pathway and Cancer Metastasis
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    Chapter 15 Notch, Apoptosis and Cancer
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    Chapter 16 Ligand-dependent notch signaling in vascular formation.
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    Chapter 17 Notch and the p53 Clan of Transcription Factors
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    Chapter 18 Notch signaling and breast cancer.
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    Chapter 19 Notch Signaling and Malignant Melanoma
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    Chapter 20 Notch-Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited
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    Chapter 21 Notch Signaling and Intestinal Cancer
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    Chapter 22 Notch Signaling and Brain Tumors
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    Chapter 23 NOTCH INHIBITION AS A PROMISING NEW APPROACH TO CANCER THERAPY
Attention for Chapter 18: Notch signaling and breast cancer.
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Chapter title
Notch signaling and breast cancer.
Chapter number 18
Book title
Notch Signaling in Embryology and Cancer
Published in
Advances in experimental medicine and biology, January 2012
DOI 10.1007/978-1-4614-0899-4_18
Pubmed ID
Book ISBNs
978-1-4614-0898-7, 978-1-4614-0899-4
Authors

Michael Reedijk

Abstract

It has been more than two decades since Notch has been identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated Notch signaling and up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer. In addition, high expression of Notch ligands and receptors has been shown to correlate with poor outcome in this malignancy. Notch affects multiple cellular processes including stem cell maintenance, cell fate specification, differentiation, proliferation, motility and survival. Perturbation of these activities is a hallmark of carcinogenesis and evidence continues to accumulate that aberrant Notch activity influences breast cancer progression through these processes.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Sweden 1 <1%
Italy 1 <1%
Unknown 106 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 38 35%
Student > Bachelor 15 14%
Researcher 13 12%
Student > Master 13 12%
Student > Doctoral Student 9 8%
Other 11 10%
Unknown 11 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 33%
Biochemistry, Genetics and Molecular Biology 35 32%
Medicine and Dentistry 12 11%
Engineering 6 5%
Mathematics 3 3%
Other 7 6%
Unknown 11 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2012.
All research outputs
#18,305,470
of 22,663,969 outputs
Outputs from Advances in experimental medicine and biology
#3,275
of 4,904 outputs
Outputs of similar age
#195,925
of 244,051 outputs
Outputs of similar age from Advances in experimental medicine and biology
#92
of 129 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,904 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,051 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.