Chapter title |
Notch signaling and breast cancer.
|
---|---|
Chapter number | 18 |
Book title |
Notch Signaling in Embryology and Cancer
|
Published in |
Advances in experimental medicine and biology, January 2012
|
DOI | 10.1007/978-1-4614-0899-4_18 |
Pubmed ID | |
Book ISBNs |
978-1-4614-0898-7, 978-1-4614-0899-4
|
Authors |
Michael Reedijk |
Abstract |
It has been more than two decades since Notch has been identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated Notch signaling and up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer. In addition, high expression of Notch ligands and receptors has been shown to correlate with poor outcome in this malignancy. Notch affects multiple cellular processes including stem cell maintenance, cell fate specification, differentiation, proliferation, motility and survival. Perturbation of these activities is a hallmark of carcinogenesis and evidence continues to accumulate that aberrant Notch activity influences breast cancer progression through these processes. |
X Demographics
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Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
United States | 1 | <1% |
Sweden | 1 | <1% |
Italy | 1 | <1% |
Unknown | 106 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 38 | 35% |
Student > Bachelor | 15 | 14% |
Researcher | 13 | 12% |
Student > Master | 13 | 12% |
Student > Doctoral Student | 9 | 8% |
Other | 11 | 10% |
Unknown | 11 | 10% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 35 | 32% |
Medicine and Dentistry | 12 | 11% |
Engineering | 6 | 5% |
Mathematics | 3 | 3% |
Other | 7 | 6% |
Unknown | 11 | 10% |