Bioinformatics and Drug Discovery

Chapter 1 Cell Perturbation Screens for Target Identification by RNAi

Chapter 2 Using Functional Genomics to Identify Drug Targets: A Dupuytren’s Disease Example

Chapter 3 Functional Characterization of Human Genes from Exon Expression and RNA Interference Results

Chapter 4 Barcode sequencing for understanding drug-gene interactions.

Chapter 5 High-Throughput Sequencing of the Methylome Using Two-Base Encoding

Chapter 6 Bioinformatics and Drug Discovery

Chapter 7 Compound Collection Preparation for Virtual Screening

Chapter 8 Mapping between databases of compounds and protein targets.

Chapter 9 Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-array and Gene Expression Data

Chapter 11 Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance

Chapter 12 Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection

Chapter 13 Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analysis

Chapter 14 Models of Excitation–Contraction Coupling in Cardiac Ventricular Myocytes

Chapter 15 Integration of Multiple Ubiquitin Signals in Proteasome Regulation