Chapter title |
Subcellular Redox Signaling
|
---|---|
Chapter number | 25 |
Book title |
Pulmonary Vasculature Redox Signaling in Health and Disease
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-63245-2_25 |
Pubmed ID | |
Book ISBNs |
978-3-31-963244-5, 978-3-31-963245-2
|
Authors |
Liping Zhu, Yankai Lu, Jiwei Zhang, Qinghua Hu, Zhu, Liping, Lu, Yankai, Zhang, Jiwei, Hu, Qinghua |
Abstract |
Oxidative and antioxidative system of cells and tissues maintains a balanced state under physiological conditions. A disruption in this balance of redox status has been associated with numerous pathological processes. Reactive oxygen species (ROS) as a major redox signaling generates in a spatiotemporally dependent manner. Subcellular organelles such as mitochondria, endoplasmic reticulum, plasma membrane and nuclei contribute to the production of ROS. In addition to downstream effects of ROS signaling regulated by average ROS changes in cytoplasm, whether subcelluar ROS mediate biological effect(s) has drawn greater attentions. With the advance in redox-sensitive probes targeted to different subcellular compartments, the investigation of subcellular ROS signaling and its associated cellular function has become feasible. In this review, we discuss the subcellular ROS signaling, with particular focus on mechanisms of subcellular ROS production and its downstream effects. |
X Demographics
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Unknown | 1 | 50% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
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Demographic breakdown
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Unspecified | 2 | 22% |
Professor | 2 | 22% |
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Student > Master | 1 | 11% |
Other | 1 | 11% |
Unknown | 1 | 11% |
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Unspecified | 2 | 22% |
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Neuroscience | 1 | 11% |
Unknown | 1 | 11% |