Chapter title |
Soluble Ligand CD40 and Uric Acid as Markers of Atheromatosis in Patients with Obstructive Sleep Apnea.
|
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Chapter number | 44 |
Book title |
Inflammatory Disorders
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Published in |
Advances in experimental medicine and biology, October 2014
|
DOI | 10.1007/5584_2014_44 |
Pubmed ID | |
Book ISBNs |
978-3-31-910011-1, 978-3-31-910012-8
|
Authors |
M. Kosacka, A. Brzecka, P. Piesiak, A. Korzeniewska, R. Jankowska |
Abstract |
The aim of the study was to evaluate the risk of atheromatosis in patients with obstructive sleep apnea (OSA), as based on the concentration of the pro-atherogenic soluble CD40L ligand (sCD40L) in relation to the level of uric acid. The serum levels of sCD40L and uric acid were measured in 79 OSA patients (mean apnea/hypopnea index - AHI 34.4 ± 20.9) and in 40 healthy controls. We found that sCD40L was higher in the OSA patients with hyperuricemia than that in the patients with uric acid in the normal range (sCD40L: 9.0 ng/ml vs. 8.0 ng/ml, respectively, p < 0.05). There was a positive association of sCD40L with AHI (p = 0.01) and a negative one with the mean minimal nocturnal SaO2 (p < 0.05). Uric acid correlated negatively with the mean and minimal SaO2 and positively with the oxygen desaturation index (p < 0.05). OSA patients with hyperuricemia also had a higher prevalence of hypertension and ischemic heart disease. We conclude that OSA patients with increased uric acid concentration have increased risk of atheromatosis, as indicated by a higher level of soluble pro-atherogenic ligand CD40, and a higher prevalence of cardiovascular adverse events. |
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