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LC-MS in Drug Analysis

Overview of attention for book
Cover of 'LC-MS in Drug Analysis'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 An Introduction to Drug Testing: The Expanding Role of Mass Spectrometry
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    Chapter 2 LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Technology for Drug Screening Assays.
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    Chapter 3 LC-MS/MS Techniques for High-Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices
  5. Altmetric Badge
    Chapter 4 Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry
  6. Altmetric Badge
    Chapter 5 Opiate Screening and Quantitation in Urine/Blood Matrices Using LC-MS/MS Techniques
  7. Altmetric Badge
    Chapter 6 Synthetic Opioid Analysis by LC-MS/MS
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    Chapter 7 The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection
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    Chapter 8 Cocaine and Metabolites by LC-MS/MS
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    Chapter 9 Quantitation of Amphetamine-Type Stimulants by LC-MS/MS
  11. Altmetric Badge
    Chapter 10 Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control
  12. Altmetric Badge
    Chapter 11 LC-MS/MS Screen for Xenobiotics and Metabolites
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    Chapter 12 Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS
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    Chapter 13 Hypoglycemic Agent Screening by LC-MS/MS
  15. Altmetric Badge
    Chapter 14 LC-MS/MS Method for the Detection of Common Laxatives
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    Chapter 15 Simultaneous determination of cyclosporine, sirolimus, and tacrolimus in whole blood using liquid chromatography-tandem mass spectrometry.
  17. Altmetric Badge
    Chapter 16 Quantification of Tricyclic Antidepressants Using UPLC-MS/MS.
  18. Altmetric Badge
    Chapter 17 Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS
  19. Altmetric Badge
    Chapter 18 Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry
  20. Altmetric Badge
    Chapter 19 Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS.
Attention for Chapter 15: Simultaneous determination of cyclosporine, sirolimus, and tacrolimus in whole blood using liquid chromatography-tandem mass spectrometry.
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Chapter title
Simultaneous determination of cyclosporine, sirolimus, and tacrolimus in whole blood using liquid chromatography-tandem mass spectrometry.
Chapter number 15
Book title
LC-MS in Drug Analysis
Published in
Methods in molecular biology, January 2012
DOI 10.1007/978-1-61779-934-1_15
Pubmed ID
22767117
Book ISBNs
978-1-61779-933-4, 978-1-61779-934-1
Authors

Uttam Garg, Ada Munar, C. Clinton Frazee, Garg, Uttam, Munar, Ada, Frazee, C. Clinton

Abstract

A multiple reaction monitoring, positive ionization electrospray, liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is described for the simultaneous quantification of cyclosporine, sirolimus, and tacrolimus in human whole blood. Proteins in the samples are precipitated with a mixture of methanol and zinc sulfate. The supernatant is injected into the LC-MS/MS for analysis. Chromatography involves the use of a C18 column and ammonium acetate/water/methanol-containing mobile phases. The MS/MS is operated in positive ion electrospray mode. Quantification is achieved by comparing peak area ratios of MRMs of analytes and internal standards with that of calibrators. Calibration curves are constructed from peak area ratios of MRMs of calibrators and internal standards versus concentrations. MRMs used are ascomycin (m/z 809.5 → 756.5), cyclosporine A (m/z 1,219.9 → 1,203.1), cyclosporine D (m/z 1,234.0 → 1,217.0), sirolimus (m/z 931.6 → 864.5), and tacrolimus (m/z 821.5 → 768.4).

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 100%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 50%
Medicine and Dentistry 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2012.
All research outputs
#18,309,495
of 22,669,724 outputs
Outputs from Methods in molecular biology
#7,827
of 13,037 outputs
Outputs of similar age
#195,952
of 244,072 outputs
Outputs of similar age from Methods in molecular biology
#325
of 473 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,037 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 473 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.

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