| Chapter title |
Plasticity of airway lymphatics in development and disease.
|
|---|---|
| Chapter number | 4 |
| Book title |
Developmental Aspects of the Lymphatic Vascular System
|
| Published in |
Advances in anatomy embryology and cell biology, November 2013
|
| DOI | 10.1007/978-3-7091-1646-3_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-70-911645-6, 978-3-70-911646-3
|
| Authors |
Yao LC, McDonald DM, Li-Chin Yao, Donald M. McDonald, Yao, Li-Chin, McDonald, Donald M. |
| Abstract |
The dynamic nature of lymphatic vessels is reflected by structural and functional modifications that coincide with changes in their environment. Lymphatics in the respiratory tract undergo rapid changes around birth, during adaptation to air breathing, when lymphatic endothelial cells develop button-like intercellular junctions specialized for efficient fluid uptake and transport. In inflammatory conditions, lymphatic vessels proliferate and undergo remodeling to accommodate greater plasma leakage and immune cell trafficking. However, the newly formed lymphatics are abnormal, and resolution of inflammation is not accompanied by complete reversal of the lymphatic vessel changes back to the baseline. As the understanding of lymphatic plasticity advances, approaches for eliminating the abnormal vessels and improving the functionality of those that remain move closer to reality. This chapter provides an overview of what is known about lymphatic vessel growth, remodeling, and other forms of plasticity that occur during development or inflammation, with an emphasis on the respiratory tract. Also addressed is the limited reversibility of changes in lymphatics during the resolution of inflammation. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 20% |
| Student > Ph. D. Student | 3 | 15% |
| Student > Bachelor | 3 | 15% |
| Professor > Associate Professor | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Other | 5 | 25% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 35% |
| Agricultural and Biological Sciences | 6 | 30% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 1 | 5% |