The Search for Antiviral Drugs

Chapter 1 Introduction: The First Effective Antiviral

Chapter 2 Discovery and Development of Zidovudine as the Cornerstone of Therapy to Control Human Immunodeficiency Virus Infection

Chapter 4 Discovery of TIBO, a New Family of HIV-1-Specific Reverse Transcriptase Inhibitors

Chapter 5 Discovery and Development of 2-Pyridinone HIV-1 Reverse Transcriptase Inhibitors

Chapter 6 Discovery and Development of the HIV Proteinase Inhibitor Ro 31-8959

Chapter 7 A New Approach to Antiviral Chemotherapy: Intervention in Viral Gene Expression by HIV Tat Antagonists

Chapter 8 Discovery of Pirodavir, a Broad-Spectrum Inhibitor of Rhinoviruses

Chapter 9 sICAM-1 as a Receptor Antagonist for Rhinoviruses: A Model System of Adhesion Molecules as Cell Receptors for Viruses

Chapter 10 Inactivation of Herpes Simplex Virus Ribonucleotide Reductase by Subunit Association Inhibitors: A Potential Antiviral Strategy