Chapter title |
Inflammasome Signaling and Bacterial Infections
|
---|---|
Chapter number | 11 |
Book title |
Inflammasome Signaling and Bacterial Infections
|
Published in |
Current topics in microbiology and immunology, January 2016
|
DOI | 10.1007/978-3-319-41171-2_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-941170-5, 978-3-31-941171-2
|
Authors |
Rabes, Anne, Suttorp, Norbert, Opitz, Bastian, Anne Rabes, Norbert Suttorp, Bastian Opitz |
Abstract |
Streptococcus pneumoniae frequently colonizes the upper respiratory tract of healthy individuals, but also commonly causes severe invasive infections such as community-acquired pneumonia and meningitis. One of the key virulence factors of pneumococci is the pore-forming toxin pneumolysin which stimulates cell death and is involved in the evasion of some defense mechanisms. The immune system, however, employs different inflammasomes to sense pneumolysin-induced pore formation, cellular membrane damage, and/or subsequent leakage of bacterial nucleic acid into the host cell cytosol. Canonical inflammasomes are cytosolic multiprotein complexes consisting of a receptor molecule such as NLRP3 or AIM2, the adapter ASC, and caspase-1. NLRP3 and AIM2 inflammasomes mediate cell death and production of important IL-1 family cytokines to recruit leukocytes and defend against S. pneumoniae. Here, we review recent evidence that highlights inflammasomes as critical sensors of S. pneumoniae-induced cellular perturbations, summarize their role in pneumococcal infections, and discuss potential evasion strategies of some emerging pneumococcal strains. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 19% |
Researcher | 5 | 14% |
Student > Master | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Student > Bachelor | 3 | 8% |
Other | 4 | 11% |
Unknown | 11 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Agricultural and Biological Sciences | 4 | 11% |
Immunology and Microbiology | 3 | 8% |
Unspecified | 2 | 5% |
Other | 2 | 5% |
Unknown | 15 | 41% |