Chapter title |
Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells
|
---|---|
Chapter number | 11 |
Book title |
Isolation and Molecular Characterization of Circulating Tumor Cells
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-55947-6_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-955946-9, 978-3-31-955947-6
|
Authors |
Stefan Werner, Arnulf Stenzl, Klaus Pantel, Tilman Todenhöfer, Werner, Stefan, Stenzl, Arnulf, Pantel, Klaus, Todenhöfer, Tilman |
Abstract |
The characterization of circulating tumor cells (CTC) has the potential not only to provide important insights into molecular alterations of advanced tumor disease but also to facilitate risk prediction. Epithelial mesenchymal transition (EMT) has been discovered as important process for the development of metastases and the dissemination of tumor cells into the blood stream. In different tumor types, CTC with a mesenchymal phenotype have been reported that have presumably underwent EMT. Moreover, CTC with stem-cell like characteristics have been postulated as important drivers of tumor progression. Different platforms have been introduced to allow CTC enrichment independent of expression of epithelial antigens, as these may be downregulated in EMT- or stem-cell-like CTC. Both for CTCs with EMT- or stem-cell features different markers have been proposed. However, there is still a lack of evidence on the association of these markers with functional features and characteristics for stem cells and cells undergoing EMT. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 28% |
Student > Bachelor | 5 | 20% |
Researcher | 4 | 16% |
Student > Master | 3 | 12% |
Other | 1 | 4% |
Other | 1 | 4% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 28% |
Business, Management and Accounting | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Earth and Planetary Sciences | 1 | 4% |
Other | 3 | 12% |
Unknown | 4 | 16% |