Chapter title |
More is better! Update of Dana-Farber Cancer Institute/Children's Hospital childhood acute lymphoblastic leukemia trials.
|
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Chapter number | 83 |
Book title |
Acute Leukemias II
|
Published in |
Haematology and blood transfusion, January 1990
|
DOI | 10.1007/978-3-642-74643-7_83 |
Pubmed ID | |
Book ISBNs |
978-3-54-050984-4, 978-3-64-274643-7
|
Authors |
Sallan, S E, Gelber, R D, Kimball, V, Donnelly, M, Cohen, H J, Sallan, S. E., Gelber, R. D., Kimball, V., Donnelly, M., Cohen, H. J. |
Abstract |
Between 1973 and 1985, 553 children with childhood acute lymphoblastic leukemia were treated on Dana-Farber Cancer Institute/Children's Hospital, Boston, protocols. The programs featured intensive remission induction therapy, CNS treatment with cranial irradiation and intrathecal drugs, doxorubicin intensification with or without asparaginase, and 2-21/2 years of conventional continuation therapy. There has been progressive improvement in event-free survival for each successive program. Leukemia control concerns pertain to: 1. late relapses (at greater than 5 years) in "standard-risk" patients; 2. an increased incidence of CNS relapses, especially in "standard-risk" patients, as preventative treatment is reduced in intensity; and 3. bone marrow relapses in "high-risk"patients. Comparisons of patients receiving the more intensive arm of each protocol with those receiving the less intensive arm support the hypothesis that more intensive chemotherapy results in improved event-free survival. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 17% |
Student > Bachelor | 3 | 13% |
Student > Master | 3 | 13% |
Student > Ph. D. Student | 3 | 13% |
Professor > Associate Professor | 2 | 8% |
Other | 2 | 8% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 38% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Agricultural and Biological Sciences | 1 | 4% |
Sports and Recreations | 1 | 4% |
Neuroscience | 1 | 4% |
Other | 0 | 0% |
Unknown | 9 | 38% |