Chapter title |
The immunotherapeutic effect of anti Lyt-1 antibodies on local and metastatic tumor growth.
|
---|---|
Chapter number | 99 |
Book title |
Microenvironments in the Lymphoid System
|
Published in |
Advances in experimental medicine and biology, January 1985
|
DOI | 10.1007/978-1-4613-2463-8_99 |
Pubmed ID | |
Book ISBNs |
978-1-4612-9495-5, 978-1-4613-2463-8
|
Authors |
Hollander, N, Hollander, Nurit |
Abstract |
Monoclonal antibodies against the T cell differentiation antigen Lyt-1 were effective in the therapy of the murine Lewis lung carcinoma (3LL). A possible mechanism whereby anti Lyt-1 antibodies directly effect the tumor cells was unlikely because 3LL cells lack the Lyt-1 antigen. In addition, the curative effect of anti Lyt-1 antibodies was abrogated in mice depleted of T cells, supporting a mechanism whereby host Lyt-1+ cells were involved in tumor therapy. Treatment with anti Lyt-1 antibodies was not accompanied by depletion of Lyt-1+ cells from lymphoid organs, indicating that the administered antibodies altered Lyt-1+ cell functions without effecting their frequency. In view of the in vitro enhancing effects of anti Lyt-1 antibodies on responses, it is suggested that the potentiation of Lyt-1+ cell activity by passively administered anti Lyt-1 antibodies results in tumor rejection. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 50% |
Professor | 1 | 25% |
Researcher | 1 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Arts and Humanities | 1 | 25% |
Computer Science | 1 | 25% |
Agricultural and Biological Sciences | 1 | 25% |
Immunology and Microbiology | 1 | 25% |