Chapter title |
Potassium transport at the blood-brain and blood-CSF barriers.
|
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Chapter number | 8 |
Book title |
Frontiers in Cerebral Vascular Biology
|
Published in |
Advances in experimental medicine and biology, January 1993
|
DOI | 10.1007/978-1-4615-2920-0_8 |
Pubmed ID | |
Book ISBNs |
978-1-4613-6267-8, 978-1-4615-2920-0
|
Authors |
Keep, R F, Xiang, J, Betz, A L, Richard F. Keep, Jianming Xiang, A. Lorris Betz, Keep, Richard F., Xiang, Jianming, Lorris Betz, A. |
Abstract |
Figure 5 gives a summary of K transporters at the BBB based on the available evidence. It appears that the cerebral endothelial cells have an array of potassium channels, although the degree to which each is open under physiological conditions is uncertain. Different channels are present on the luminal and abluminal membranes, and the opening and closing of these channels may allow modulation of the brain K influx and efflux rates and play a role in brain K homeostasis. These channels may also play a role in hyperosmotic brain volume regulation by increasing the entry rate of potassium into brain and may be involved in volume regulation of the endothelial cell itself. The nature of fluid transport at the BBB remains to be fully elucidated, with the presence of a Na/K/2Cl co-transporter being uncertain. The abluminal inwardly-rectifying channel may act as a leak pathway to allow modulation of fluid secretion by the Na/K ATPase without altering the K concentration of that fluid. Finally, there is some evidence that K transport at the BBB is under hormonal and neuronal control. The cerebral capillaries possess receptors for many of the hormones present in blood and brain. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 25% |
Student > Bachelor | 1 | 13% |
Other | 1 | 13% |
Student > Master | 1 | 13% |
Professor > Associate Professor | 1 | 13% |
Other | 0 | 0% |
Unknown | 2 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 50% |
Neuroscience | 1 | 13% |
Agricultural and Biological Sciences | 1 | 13% |
Unknown | 2 | 25% |