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Frontiers in Cerebral Vascular Biology

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Cover of 'Frontiers in Cerebral Vascular Biology'

Table of Contents

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    Book Overview
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    Chapter 1 Developmental Expression of Glucose Transporters, Glut1 and Glut3, in Postnatal Rat Brain
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    Chapter 2 Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats
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    Chapter 3 Glucose Transporter (Glut1) Expression by Canine Brain Microvessel Endothelial Cells in Culture: An Immunocytochemical Study
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    Chapter 4 Application of Novel PCR Strategies to Amplify and Sequence Glucose Transporters in Canine Brain
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    Chapter 5 Estimation of Unidirectional Clearances of FDG and Glucose Across the Blood-Brain Barrier in Man
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    Chapter 6 Rat Brain Glucose Concentration and Transport Kinetics Determined with 13 C Nuclear Magnetic Resonance Spectroscopy
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    Chapter 7 Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13 C Nuclear Magnetic Resonance
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    Chapter 8 Potassium transport at the blood-brain and blood-CSF barriers.
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    Chapter 9 Expression of Na, K-ATPase at the Blood-Brain Interface
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    Chapter 10 Effects of Protein Kinase C Agonists on Na, K-ATPase Activity in Rat Brain Microvessels
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    Chapter 12 The Transendothelial DC Potential of Rat Blood-Brain Barrier Vessels in Situ
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    Chapter 13 Phosphate Transport in Capillaries of the Blood-Brain Barrier
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    Chapter 14 Drug Delivery to Brain and the Role of Carrier-Mediated Transport
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    Chapter 15 Vasopressin Modulates the Blood-Brain Transfer of Amino Acids-Studies with [ 11 C]Methionine in Dogs
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    Chapter 16 Amino Acid Transport at the Blood-Nerve Barrier of the Rat Peripheral Nerve
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    Chapter 17 Effect of Intra-Uterine Growth Retardation on Cerebral Amino Acid Transport from Birth to Adulthood
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    Chapter 18 Drug Transfer Across the Blood-Brain Barrier: Comparison of in Vitro and in Vivo Models
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    Chapter 19 Differential Brain Penetration of Cerebroprotective Drugs
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    Chapter 20 P-Glycoprotein is Strongly Expressed in Brain Capillaries
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    Chapter 21 Transport of Proteins Across the Blood-Brain Barrier via the Transferrin Receptor
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    Chapter 22 Endothelial Cell Biology and the Enigma of Transcytosis Through the Blood-Brain Barrier
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    Chapter 23 Blood-Brain Transport of Vasopressin
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    Chapter 24 Cerebral Pericytes — A Second Line of Defense in Controlling Blood-Brain Barrier Peptide Metabolism
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    Chapter 25 The Role of Second Messenger Molecules in the Regulation of Permeability in the Cerebral Endothelial Cells
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    Chapter 26 Peptidergic Induction of Endothelin 1 and Prostanoid Secretion in Human Cerebromicrovascular Endothelium
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    Chapter 27 Endothelin-1 Binding to Human Brain Microvascular and Capillary Endothelium: Membranes vs. Intact Cells
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    Chapter 28 Possible Involvement of C-Kinase in Occurrence of Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage
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    Chapter 29 A Novel Gene Family May Encode Endothelial Cell Specific Adhesion-Like Molecules: An Extracellular Loop-Repeat-Loop (LRL) Motif and Cytoplasmic Tyrosine Kinase Domains
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    Chapter 30 Plasminogen Activation and Astroglial-Induced Neural Microvessel Morphogenesis
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    Chapter 31 Immortalized Rat Brain Microvessel Endothelial Cells: I - Expression of Blood-Brain Barrier Markers During Angiogenesis
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    Chapter 32 Immortalized Rat Brain Microvessel Endothelial Cells: II-Pharmacological Characterization
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    Chapter 33 Expression of the HT7 Gene in Blood-Brain Barrier
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    Chapter 34 Astrocytes Secrete a Factor Inducing the Expression of HT7-Protein and Neurothelin in Endothelial Cells of Chorioallantoic Vessels
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    Chapter 35 Chorioallantoic Membrane (CAM) Vessels do not Respond to Blood-Brain Barrier (BBB) Induction
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    Chapter 36 Cerebral Endothelium and Astrocytes Cooperate in Supplying Docosahexaenoic Acid to Neurons
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    Chapter 37 Effect of cytokines on ICAM expression and T cell adhesion to cerebrovascular endothelial cells.
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    Chapter 39 Generation of an Anti-Mouse Brain Endothelial Cell Monoclonal Antibody that Recognizes 84-110 kDa and 36 kDa Determinants that are Upregulated by Cytokines
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    Chapter 40 The Use of Intracerebral Microdialysis to Study Blood-Brain Barrier Transport in Health, After Modification and in Disease
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    Chapter 41 Cerebral Endothelial Mechanisms in Increased Permeability in Chronic Hypertension
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    Chapter 42 Altered Fatty Acid Composition of Ethanolamine Phosphoglyceride in Brain Microvessels from Senescent Mouse
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    Chapter 43 Preirradiation Osmotic Blood-Brain Barrier Disruption Plus Combination Chemotherapy in Gliomas: Quantitation of Tumor Response to Assess Chemosensitivity
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    Chapter 44 The Uptake of Thyroxine by the Isolated Perfused Choroid Plexus of the Sheep
Attention for Chapter 8: Potassium transport at the blood-brain and blood-CSF barriers.
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Chapter title
Potassium transport at the blood-brain and blood-CSF barriers.
Chapter number 8
Book title
Frontiers in Cerebral Vascular Biology
Published in
Advances in experimental medicine and biology, January 1993
DOI 10.1007/978-1-4615-2920-0_8
Pubmed ID
Book ISBNs
978-1-4613-6267-8, 978-1-4615-2920-0

Keep, R F, Xiang, J, Betz, A L, Richard F. Keep, Jianming Xiang, A. Lorris Betz


Figure 5 gives a summary of K transporters at the BBB based on the available evidence. It appears that the cerebral endothelial cells have an array of potassium channels, although the degree to which each is open under physiological conditions is uncertain. Different channels are present on the luminal and abluminal membranes, and the opening and closing of these channels may allow modulation of the brain K influx and efflux rates and play a role in brain K homeostasis. These channels may also play a role in hyperosmotic brain volume regulation by increasing the entry rate of potassium into brain and may be involved in volume regulation of the endothelial cell itself. The nature of fluid transport at the BBB remains to be fully elucidated, with the presence of a Na/K/2Cl co-transporter being uncertain. The abluminal inwardly-rectifying channel may act as a leak pathway to allow modulation of fluid secretion by the Na/K ATPase without altering the K concentration of that fluid. Finally, there is some evidence that K transport at the BBB is under hormonal and neuronal control. The cerebral capillaries possess receptors for many of the hormones present in blood and brain.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 1 20%
Student > Bachelor 1 20%
Researcher 1 20%
Unknown 2 40%
Readers by discipline Count As %
Medicine and Dentistry 2 40%
Agricultural and Biological Sciences 1 20%
Unknown 2 40%