| Chapter title |
CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us?
|
|---|---|
| Chapter number | 2 |
| Book title |
Chromosomal Instability in Cancer Cells
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, September 2015
|
| DOI | 10.1007/978-3-319-20291-4_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-920290-7, 978-3-31-920291-4
|
| Authors |
Simon, Judith E, Bakker, Bjorn, Foijer, Floris, Simon, Judith E., Judith E. Simon, Bjorn Bakker, Floris Foijer |
| Abstract |
Chromosomal instability (CIN) is a process leading to errors in chromosome segregation and results in aneuploidy, a state in which cells have an abnormal number of chromosomes. CIN is a hallmark of cancer, and furthermore linked to ageing and age-related diseases such as Alzheimer's. Various mouse models have been developed to explore the role of CIN in ageing and cancer. While these models reveal only a modest contribution of CIN to the initiation of cancer, they also clearly show that CIN is a powerful accelerator of cancer in a predisposed background. Other than cancer, CIN also appears to provoke premature ageing in some of the CIN models. In this review, we discuss the phenotypes of the various available mouse models, what we have learnt so far, and importantly, also which questions still need to be addressed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Netherlands | 1 | 2% |
| Unknown | 50 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 40% |
| Student > Bachelor | 8 | 15% |
| Student > Master | 6 | 12% |
| Researcher | 3 | 6% |
| Student > Postgraduate | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 7 | 13% |
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|---|---|---|
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| Medicine and Dentistry | 2 | 4% |
| Mathematics | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 9 | 17% |