Chapter title |
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
|
---|---|
Chapter number | 26 |
Book title |
Reviews of Physiology, Biochemistry and Pharmacology Vol. 169
|
Published in |
Reviews of Physiology, Biochemistry and Pharmacology, January 2015
|
DOI | 10.1007/112_2015_26 |
Pubmed ID | |
Book ISBNs |
978-3-31-926563-6, 978-3-31-926565-0
|
Authors |
Eric Honoré, Joana Raquel Martins, David Penton, Amanda Patel, Sophie Demolombe, Honoré, Eric, Martins, Joana Raquel, Penton, David, Patel, Amanda, Demolombe, Sophie |
Abstract |
Piezo1 and Piezo2 are critically required for nonselective cationic mechanosensitive channels in mammalian cells. Within the last 5 years, tremendous progress has been made in understanding the function of Piezo1/2 in embryonic development, physiology, and associated disease states. A recent breakthrough was the discovery of a chemical opener for Piezo1, indicating that mechanosensitive ion channels can be opened independently of mechanical stress. We will review these new exciting findings, which might pave the road for the identification of novel therapeutic strategies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 56 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 22% |
Researcher | 9 | 16% |
Student > Bachelor | 9 | 16% |
Student > Master | 7 | 12% |
Student > Postgraduate | 3 | 5% |
Other | 8 | 14% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 28% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Medicine and Dentistry | 7 | 12% |
Engineering | 6 | 10% |
Neuroscience | 5 | 9% |
Other | 2 | 3% |
Unknown | 13 | 22% |