Chapter title |
Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches
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Chapter number | 57 |
Book title |
Targeting Trafficking in Drug Development
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Published in |
Handbook of experimental pharmacology, January 2017
|
DOI | 10.1007/164_2017_57 |
Pubmed ID | |
Book ISBNs |
978-3-31-974163-5, 978-3-31-974164-2
|
Authors |
Simon R. Foster, Hans Bräuner-Osborne, Foster, Simon R., Bräuner-Osborne, Hans |
Abstract |
The ability to regulate the interaction between cells and their extracellular environment is essential for the maintenance of appropriate physiological function. For G protein-coupled receptors (GPCRs), this regulation occurs through multiple mechanisms that provide spatial and temporal control for signal transduction. One of the major mechanisms for GPCR regulation involves their endocytic trafficking, which serves to internalize the receptors from the plasma membrane and thereby attenuate G protein-dependent signaling. However, there is accumulating evidence to suggest that GPCRs can signal independently of G proteins, as well as from intracellular compartments including endosomes. It is in this context that receptor internalization and intracellular trafficking have attracted renewed interest within the GPCR field. In this chapter, we will review the current understanding and methodologies that have been used to investigate internalization and intracellular signaling of GPCRs, with a particular focus on emerging real-time techniques. These recent developments have improved our understanding of the complexities of GPCR internalization and intracellular signaling and suggest that the broader biological relevance and potential therapeutic implications of these processes remain to be explored. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 33% |
Student > Bachelor | 9 | 15% |
Other | 5 | 8% |
Student > Master | 5 | 8% |
Researcher | 4 | 7% |
Other | 5 | 8% |
Unknown | 13 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 13% |
Agricultural and Biological Sciences | 8 | 13% |
Medicine and Dentistry | 3 | 5% |
Engineering | 2 | 3% |
Other | 5 | 8% |
Unknown | 15 | 25% |