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Chemical Proteomics

Overview of attention for book
Cover of 'Chemical Proteomics'

Table of Contents

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    Book Overview
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    Chapter 1 Mass Spectrometry-Based Chemoproteomic Approaches
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    Chapter 2 Chemical Proteomics in Drug Discovery
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    Chapter 3 Compound immobilization and drug-affinity chromatography.
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    Chapter 4 Affinity-Based Chemoproteomics with Small Molecule-Peptide Conjugates
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    Chapter 5 A Chemical Proteomic Probe for Detecting Dehydrogenases: Catechol Rhodanine
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    Chapter 6 Probing proteomes with benzophenone photoprobes.
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    Chapter 7 Biotinylated Probes for the Analysis of Protein Modification by Electrophiles
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    Chapter 8 Profiling of Methyltransferases and Other S -Adenosyl- l -Homocysteine-Binding Proteins by Capture Compound Mass Spectrometry
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    Chapter 9 Identifying Cellular Targets of Small-Molecule Probes and Drugs with Biochemical Enrichment and SILAC.
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    Chapter 10 Determination of Kinase Inhibitor Potencies in Cell Extracts by Competition Binding Assays and Isobaric Mass Tags
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    Chapter 11 Affinity-Based Profiling of Dehydrogenase Subproteomes
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    Chapter 12 Probing the Specificity of Protein–Protein Interactions by Quantitative Chemical Proteomics
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    Chapter 13 Fluorescence-Based Proteasome Activity Profiling
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    Chapter 14 Chemical Cross-Linking and High-Resolution Mass Spectrometry to Study Protein–Drug Interactions
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    Chapter 15 Monitoring Ligand Modulation of Protein–Protein Interactions by Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry
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    Chapter 16 Time-Controlled Transcardiac Perfusion Crosslinking for In Vivo Interactome Studies
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    Chapter 17 Ligand Discovery Using Small-Molecule Microarrays
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    Chapter 18 Working with Small Molecules: Preparing and Storing Stock Solutions and Determination of Kinetic Solubility
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    Chapter 19 A Database for Chemical Proteomics: ChEBI.
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    Chapter 20 Working with Small Molecules: Rules-of-Thumb of “Drug Likeness”
Attention for Chapter 6: Probing proteomes with benzophenone photoprobes.
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Chapter title
Probing proteomes with benzophenone photoprobes.
Chapter number 6
Book title
Chemical Proteomics
Published in
Methods in molecular biology, January 2012
DOI 10.1007/978-1-61779-364-6_6
Pubmed ID
22065219
Book ISBNs
978-1-61779-363-9, 978-1-61779-364-6
Authors

Akira Kawamura, Doina M. Mihai, Kawamura, Akira, Mihai, Doina M.

Abstract

Benzophenone photoprobes represent powerful tools for chemical proteomics. Upon UV irradiation, a benzophenone photoprobe can selectively form a covalent bond with its target protein in complex protein mixtures. Thus, photoprobes can be used to profile a wide variety of proteins in complex proteomes. This chapter describes simple protocols to derivatize fluorenylmethyloxycarbonyl (Fmoc)-protected peptide-nucleic-acid adenine (PNA adenine) into a benzophenone photoprobe and its application in photolabeling its target proteins. The method as described does not require specialized equipment for probe synthesis and photolabeling. In addition, the strategy is applicable to recognition motifs other than PNA adenine, such as peptides, to profile their target proteins in complex proteomes.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Student > Bachelor 2 18%
Student > Postgraduate 2 18%
Student > Master 2 18%
Student > Ph. D. Student 1 9%
Other 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 45%
Biochemistry, Genetics and Molecular Biology 3 27%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Medicine and Dentistry 1 9%
Chemistry 1 9%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2011.
All research outputs
#18,300,116
of 22,656,971 outputs
Outputs from Methods in molecular biology
#7,803
of 13,015 outputs
Outputs of similar age
#195,908
of 244,031 outputs
Outputs of similar age from Methods in molecular biology
#325
of 473 outputs
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So far Altmetric has tracked 13,015 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 473 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.

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