| Chapter title |
Cancer Stem Cells
|
|---|---|
| Chapter number | 2 |
| Book title |
Molecular Radio-Oncology
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, June 2016
|
| DOI | 10.1007/978-3-662-49651-0_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-249649-7, 978-3-66-249651-0
|
| Authors |
Woodward, Wendy A., Hill, Richard P., Wendy A. Woodward, Richard P. Hill |
| Abstract |
The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations. The simple hypothesis that stem cell therapies will overcome the minority of cells that lead to recurrence has evolved with it. Nevertheless, the body of evidence that this field is clinically relevant in patients and patient care has grown with the complexity of the hypotheses, and numerous clinical strategies to target these cells have been identified. Herein we review this progress and highlight the work still outstanding. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 19% |
| Student > Ph. D. Student | 3 | 11% |
| Researcher | 3 | 11% |
| Student > Master | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 8 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 22% |
| Medicine and Dentistry | 4 | 15% |
| Unspecified | 2 | 7% |
| Chemistry | 2 | 7% |
| Agricultural and Biological Sciences | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 8 | 30% |