Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology

Nikolaj Bak, Bob Oranje, Bak, Nikolaj, Oranje, Bob

Electroencephalography (EEG) and magnetic resonance imaging are two popular methodologies for brain research. While EEG has a high temporal resolution, yet a low spatial resolution, MRI has the complete opposite, a high spatial resolution, yet a low temporal resolution. Obviously therefore, researchers have been searching for ways combining the two methodologies, for more than two decades. However, there are many issues that have to be solved before the methodologies can be successfully and, more importantly reliably, combined. Here, we give an overview of these issues, and present strategies that have been used over the past two decades to overcome them. We start with a general description of EEG and (f)MRI methodology, then present the difficulties involved in combining both methodologies, and lastly present and discuss the most popular strategies that have been used over the past two decades to solve these problems. We conclude that in spite of the many issues, the two methodologies can be combined successfully, provided that the correct procedures are followed.