| Chapter title |
Staphylococcus aureus Pore-Forming Toxins
|
|---|---|
| Chapter number | 16 |
| Book title |
Staphylococcus aureus
|
| Published in |
Current topics in microbiology and immunology, January 2016
|
| DOI | 10.1007/82_2016_16 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-972061-6, 978-3-31-972063-0
|
| Authors |
Tamara Reyes-Robles, Victor J. Torres, Reyes-Robles, Tamara, Torres, Victor J. |
| Abstract |
Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-forming toxins. These toxins play several roles in pathogenesis, including disruption of cellular adherens junctions at epithelial barriers, alteration of intracellular signaling events, modulation of host immune responses, and killing of eukaryotic immune and non-immune cells. This chapter provides an updated overview on the S. aureus beta-barrel pore-forming cytotoxins, the identification of toxin receptors on host cells, and their roles in pathogenesis. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 29% |
| Student > Ph. D. Student | 7 | 21% |
| Student > Doctoral Student | 2 | 6% |
| Student > Master | 2 | 6% |
| Professor | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 10 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 24% |
| Immunology and Microbiology | 7 | 21% |
| Biochemistry, Genetics and Molecular Biology | 5 | 15% |
| Engineering | 2 | 6% |
| Chemistry | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 29% |