Chapter title |
Wnt signaling in stem cells and lung cancer.
|
---|---|
Chapter number | 43 |
Book title |
Cancer Stem Cells
|
Published in |
Ernst Schering Foundation symposium proceedings, January 2006
|
DOI | 10.1007/2789_2007_043 |
Pubmed ID | |
Book ISBNs |
978-3-54-070852-0, 978-3-54-070853-7
|
Authors |
B. He, D. M. Jablons, He, B., Jablons, D. M. |
Abstract |
The Wnt signal transduction pathway plays important roles during embryo development, regulating cell proliferation and survival of immature cells. However, its improper function can lead to harmful consequences for humans, such as aberrant cell proliferation and, therefore, cancer. Increasing evidence suggests that stem cells may be the source of mutant cells that cause cancers to develop and proliferate. Wnt signaling has been shown to promote self-renewal in both gut epithelial and hematopoietic stem cells (HSCs) and to trigger critical pathways in carcinogenesis. Although the function of stem cells in solid tumor development is unclear, the Wnt pathway's role in determining the fate and self-renewal potential of cancer stem cells suggests a critical role in carcinogenesis. The development of new inhibitors, such as antibodies or small molecules, to inhibit this pathway may be of great therapeutic utility against cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 33% |
Student > Master | 2 | 13% |
Student > Bachelor | 2 | 13% |
Other | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 47% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Immunology and Microbiology | 1 | 7% |
Social Sciences | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 13% |