Chapter title |
Examining potassium channel function in astrocytes.
|
---|---|
Chapter number | 18 |
Book title |
Astrocytes
|
Published in |
Methods in molecular biology, January 2012
|
DOI | 10.1007/978-1-61779-452-0_18 |
Pubmed ID | |
Book ISBNs |
978-1-61779-451-3, 978-1-61779-452-0
|
Authors |
Michelle Olsen, Olsen, Michelle |
Abstract |
Electrophysiologically, astrocytes are characterized by a high K(+) resting conductance and a hyperpolarized resting membrane potential. Both features are due to the activity of astrocytic potassium channels. Astrocytes express a variety of voltage-dependent and leak potassium channels on the plasma membrane that contribute to the hyperpolarized resting membrane potential and other cellular processes. This chapter focuses on measuring K(+) channel function in astrocytes, focusing on Kir4.1, an inwardly rectifying potassium channel. We and others have demonstrated that Kir4.1 contributes significantly to the high-resting K(+) conductance and the hyperpolarized resting membrane potential. This channel is also implicated in channel-mediated regulation of extracellular potassium. |
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