You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Chapter title |
The influence of niacin and nicotinamide on in vivo carcinogenesis.
|
---|---|
Chapter number | 24 |
Book title |
Essential Nutrients in Carcinogenesis
|
Published in |
Advances in experimental medicine and biology, January 1986
|
DOI | 10.1007/978-1-4613-1835-4_24 |
Pubmed ID | |
Book ISBNs |
978-1-4612-9025-4, 978-1-4613-1835-4
|
Authors |
George T. Bryan, Bryan, George T. |
Abstract |
Data concerning effects of the essential vitamin niacin and its active form nicotinamide were evaluated. Dietary deficiencies and excesses of these nutrients by themselves do not appear to exert any influence on in vivo carcinogenesis in animals. Varying results were produced when nicotinamide was administered at pharmacologic doses concurrently with or following carcinogen administration to mice or rats. Some investigators found significantly increased tumor formation, whereas others reported a decreased effect or no effect. Epidemiologic studies have not investigated the relationship between niacin deficiency or excess and carcinogenesis in humans. |