Chapter title |
Role of Drebrin at the Immunological Synapse
|
---|---|
Chapter number | 15 |
Book title |
Drebrin
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-4-431-56550-5_15 |
Pubmed ID | |
Book ISBNs |
978-4-43-156548-2, 978-4-43-156550-5
|
Authors |
Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid, V Rocha-Perugini, M Gordon-Alonso, F Sánchez-Madrid, Rocha-Perugini, Vera, Gordon-Alonso, Mónica, Sánchez-Madrid, Francisco |
Abstract |
Although drebrin was first described in neurons, it is also expressed in cells of the immune system, such as T lymphocytes and mast cells. Another member of the drebrin family of proteins, mammalian actin-binding protein 1 (mAbp-1) is more widely expressed and plays important roles in the function of macrophages, polymorphonuclear neutrophils, and B lymphocytes. We will briefly discuss on the function of mAbp-1 and drebrin in immune cells with emphasis on T cells. Specifically, drebrin enables the immune responses of CD4(+) T lymphocytes. T cells are activated after the recognition of an antigen presented by antigen-presenting cells through cognate cell-cell contacts called immunological synapses (IS). In CD4(+) T cells, drebrin associates with the chemokine receptor CXCR4, and both molecules redistribute to the IS displaying similar dynamics. Through its interaction with CXCR4 and the actin cytoskeleton, drebrin regulates T cell activation. CD4(+) T cells are one of the main targets for the human immunodeficiency virus (HIV)-1. This virus utilizes the IS structure to be transmitted to uninfected cells, forming cell-cell contacts called virological synapses (VS). Interestingly, drebrin negatively regulates HIV-1 infection of CD4(+) T lymphocytes, by regulating actin polymerization at the VS. |
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