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Chemogenomics and Chemical Genetics

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Cover of 'Chemogenomics and Chemical Genetics'

Table of Contents

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    Book Overview
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    Chapter 1 The pharmacological screening process: the small molecule, the biological Screen, the robot, the signal and the information
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    Chapter 2 Collections of molecules for screening: example of the french national chemical library
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    Chapter 3 The miniaturised biological assay: constraints and limitations
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    Chapter 4 The signal: statistical aspects, normalisation, elementary analysis
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    Chapter 5 Measuring Bioactivity: KI, IC50 and EC50
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    Chapter 6 Modelling the pharmacological screening: controlling the processes and the chemical, biological and experimental information
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    Chapter 7 Quality procedures in automated screening
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    Chapter 8 Phenotypic Screening with Cells and Forward Chemical Genetics Strategies
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    Chapter 9 High-Content Screening in Forward (Phenotypic Screening with Organisms) and Reverse (Structural Screening by NMR ) Chemical Genetics
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    Chapter 10 Some Principles of Diversity-Oriented Synthesis
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    Chapter 11 Molecular Descriptors and Similarity Indices
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    Chapter 12 Molecular Lipophilicity: A Predominant Descriptor for QSAR
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    Chapter 13 Annotation and classification of chemical space in chemogenomics
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    Chapter 14 Annotation and classification of biological space in chemogenomics
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    Chapter 15 Machine learning and screening data
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    Chapter 16 Virtual screening by molecular docking
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    Chapter 17 Biodiversity as a source of small molecules for pharmacological screening: libraries of plant extracts
Attention for Chapter 6: Modelling the pharmacological screening: controlling the processes and the chemical, biological and experimental information
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Chapter title
Modelling the pharmacological screening: controlling the processes and the chemical, biological and experimental information
Chapter number 6
Book title
Chemogenomics and Chemical Genetics
Published by
Springer, Berlin, Heidelberg, January 2011
DOI 10.1007/978-3-642-19615-7_6
Book ISBNs
978-3-64-219614-0, 978-3-64-219615-7
Authors

Sylvaine Roy