| Chapter title |
The role of glutamate in dementia.
|
|---|---|
| Chapter number | 24 |
| Book title |
Ageing and Dementia
|
| Published in |
Journal of neural transmission Supplementum, January 1998
|
| DOI | 10.1007/978-3-7091-6467-9_24 |
| Pubmed ID | |
| Book ISBNs |
978-3-21-183114-4, 978-3-70-916467-9
|
| Authors |
J Kornhuber, J Wiltfang, J Kornbuber, Kornbuber, J., Wiltfang, J. |
| Abstract |
Glutamate is an excitatory neurotransmitter, but may also act as an endogenous neurotoxin. There is good evidence for an involvement of the glutamatergic system in the pathophysiology of dementia. The glutamatergic transmission machinery is quite complex and provides a gallery of possible drug targets. There are good arguments both for an agonist and an antagonist strategy. When following the antagonist strategy, the goal is to provide neuroprotective effects via glutamate receptor antagonisms without inhibiting the physiological transmission that is required for learning and memory formation. When following the agonist strategy, the goal is to activate glutamatergic transmission without neurotoxic side effects. Several available antidementia drugs may modulate the glutamatergic transmission. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 6% |
| Unknown | 32 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 21% |
| Student > Ph. D. Student | 5 | 15% |
| Student > Master | 4 | 12% |
| Researcher | 3 | 9% |
| Professor | 2 | 6% |
| Other | 5 | 15% |
| Unknown | 8 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 18% |
| Computer Science | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Chemistry | 3 | 9% |
| Neuroscience | 3 | 9% |
| Other | 7 | 21% |
| Unknown | 9 | 26% |