Chapter title |
Immune Human Antibody Libraries for Infectious Diseases
|
---|---|
Chapter number | 4 |
Book title |
Recombinant Antibodies for Infectious Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-72077-7_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-972076-0, 978-3-31-972077-7
|
Authors |
Chan, Soo Khim, Lim, Theam Soon |
Abstract |
The incident of two children in Europe who died of diphtheria due to a shortage of anti-toxin drugs has highlighted the need for alternative anti-toxins. Historically, antiserum produced from immunised horses have been used to treat diphtheria. Despite the potential of antiserum, the economical and medial concerns associated with the use of animal antiserum has led to its slow market demise. Over the years, new and emerging infectious diseases have grown to be a major global health threat. The emergence of drug-resistant superbugs has also pushed the boundaries of available therapeutics to deal with new infectious diseases. Antibodies have emerged as a possible alternative to combat the continuous onslaught of various infectious agents. The isolation of antibodies against pathogens of infectious diseases isolated from immune libraries utilising phage display has yielded promising results in terms of affinities and neutralizing activities. This chapter focuses on the concept of immune antibody libraries and highlights the application of immune antibody libraries to generate antibodies for various infectious diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 20% |
Student > Master | 5 | 12% |
Researcher | 4 | 10% |
Student > Bachelor | 3 | 7% |
Lecturer > Senior Lecturer | 2 | 5% |
Other | 4 | 10% |
Unknown | 15 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 32% |
Medicine and Dentistry | 3 | 7% |
Environmental Science | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Economics, Econometrics and Finance | 1 | 2% |
Other | 3 | 7% |
Unknown | 19 | 46% |