| Chapter title |
Islet Amyloid Polypeptide: Aggregation and Fibrillogenesisin vitroand Its Inhibition.
|
|---|---|
| Chapter number | 8 |
| Book title |
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
|
| Published in |
Sub cellular biochemistry, December 2012
|
| DOI | 10.1007/978-94-007-5416-4_8 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-075415-7, 978-9-40-075416-4
|
| Authors |
Seeliger J, Winter R, Janine Seeliger, Roland Winter, Seeliger, Janine, Winter, Roland |
| Abstract |
The development of type 2 diabetes mellitus is associated with the dysfunction of b-cells which is correlated to the formation of deposits consisting of the islet amyloid polypeptide (IAPP). The process of human IAPP (hIAPP) self-association, the intermediate structures formed as well as the interaction of hIAPP with membrane systems seem to be responsible for the cytotoxicity. For monomeric hIAPP, a natively random coil conformation with transient a-helical parts could be determined in bulk solution, which rapidly converts to an amyloid structure consisting of cross b-sheets. By comparing the amyloidogenic propensities of hIAPP in the bulk and in the presence of various neutral and charged lipid bilayer systems as well as biological membranes, an enhancing effect of anionic and heterogeneous membranes to hIAPP fibril formation has been found. We also discuss the cross-interaction of hIAPP with other amyloidogenic peptides (e.g., insulin and Ab) and present first small-molecule inhibitors of the fibrillation process of hIAPP. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 21% |
| Student > Doctoral Student | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Professor > Associate Professor | 2 | 11% |
| Student > Ph. D. Student | 2 | 11% |
| Other | 4 | 21% |
| Unknown | 3 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 16% |
| Agricultural and Biological Sciences | 3 | 16% |
| Chemistry | 3 | 16% |
| Medicine and Dentistry | 2 | 11% |
| Nursing and Health Professions | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 4 | 21% |