Chapter title |
Somatomedin and growth hormone in psychosocial dwarfism.
|
---|---|
Chapter number | 1 |
Book title |
Aktuelle Probleme der pädiatrischen Endokrinologie
|
Published in |
Pädiatrie und Pädologie Supplementum, January 1977
|
DOI | 10.1007/978-3-7091-8491-2_1 |
Pubmed ID | |
Book ISBNs |
978-3-21-181440-6, 978-3-70-918491-2
|
Authors |
P Saenger, L S Levine, E Wiedemann, E Schwartz, S Korth-Schutz, J Pareira, B Heinig, M I New, Saenger, P, Levine, L S, Wiedemann, E, Schwartz, E, Korth-Schutz, S, Pareira, J, Heinig, B, New, M I, P. Saenger, Lenore S. Levine, E. Wiedemann, E. Schwartz, Sigrun Korth-Schutz, Judith Pareira, B. Heinig, Prof. Dr. Maria I. New, Saenger, P., Levine, Lenore S., Wiedemann, E., Schwartz, E., Korth-Schutz, Sigrun, Pareira, Judith, Heinig, B., New, Maria I., Maria I. New |
Abstract |
The diagnosis of psychosocial dwarfism (PSD) was made in a 7 year old boy upon admission to the hospital. In the period following admission, he grew at a slightly accelerated rate of 0.6 cm in 24 days (extrapolated growth rate--9.1 cm/yr); his caloric intake was 1663 calories/day (147 cal/kg/day), stimulable growth hormone was 5.9 ng/ml and somatomedin activity was in the hypopituitary range (0.24, 0.05 U/ml). In the following period of marked catch-up growth of 8.6 cm in 102 days (extrapolated growth rate 30.8 cm/yr), his caloric intake decreased significantly to 1514 cal/day (106 cal/kg/day, 0.005 less than p less than 0.01), stimulable growth hormone in this period was 13.6 ng/ml and somatomedin activity normalized (0.98 U/ml). While under continued observation, with separation from his favorite nurse, his growth velocity dropped significantly to the rate immediately following admission, but there was no change in his stimulable growth hormone or in somatomedin activity. With the return of his favorite nurse, he resumed his previous rapid catch-up growth with no change in caloric intake (p equals not significant), growth hormone level, or somatomedin activity. Upon transient return to his depriving home, his growth rate decreased to 1.4 cm in 70 days (extrapolated growth rate 7.2 cm/yr); growth hormone remained in the normal range. Somatomedin activity was in the low normal range (0.57 U/ml) and rose to high normal activity (1.31 U/ml) as rapid catch-up growth resumed after he had been readmitted. We conclude from these data that: 1. Serum somatomedin in longstanding untreated PSD may be in the hypopituitary range. 2. Markedly fluctuating growth rates during recovery in this patient with PSD were not due to changes in caloric nutrition, growth hormone release or somatomedin activity, but to an as yet unidentified factor affecting growth during emotional stress. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 8 | 40% |
United States | 1 | 5% |
Unknown | 11 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 19 | 95% |
Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Ethiopia | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 29% |
Lecturer | 1 | 14% |
Professor | 1 | 14% |
Researcher | 1 | 14% |
Professor > Associate Professor | 1 | 14% |
Other | 1 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 57% |
Psychology | 1 | 14% |
Agricultural and Biological Sciences | 1 | 14% |
Unknown | 1 | 14% |