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INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression

Overview of attention for article published in Cell & Bioscience, April 2018
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Mentioned by

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3 tweeters

Citations

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3 Dimensions

Readers on

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4 Mendeley
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Title
INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression
Published in
Cell & Bioscience, April 2018
DOI 10.1186/s13578-018-0224-4
Pubmed ID
Authors

Hongyu Guan, Yan Guo, Liehua Liu, Runyi Ye, Weiwei Liang, Hai Li, Haipeng Xiao, Yanbing Li

Abstract

Innate immunity activator (INAVA) has been shown to be elevated in lung adenocarcinoma. However, its expression pattern and function in papillary thyroid cancer (PTC) are unknown. This study aimed to identify the clinical, biological, and mechanistic impacts of INAVA on PTC. Using The Cancer Genome Atlas dataset, real time PCR, and immunohistochemistry, the expression of INAVA in PTC was analyzed. Gain- and loss-of-function assays were performed to investigate the role of INAVA in PTC cell invasion, migration, and metastasis. We explored the molecular mechanisms underlying the roles of INAVA in PTC cells using transcriptome resequencing, real time PCR, western blotting and immunohistochemistry. We found that INAVA expression was significantly upregulated in PTC and was significantly associated with lymph node metastasis. Loss- and gain-of-function experiments demonstrated that INAVA promoted the aggressive phenotype of PTC cells in vitro and in vivo. Mechanistic study suggested that upregulation of INAVA resulted in elevated fibroblast growth factor 1 (FGF1), which in turn increased the expression level of matrix metalloproteinases 9 (MMP9). We further identified that the level of INAVA was positively correlated with the levels of FGF1 and MMP9 in clinical PTC specimens. These data establish a novel role for INAVA in promoting PTC progression and suggest that INAVA may represent a therapeutic target for the disease.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 25%
Librarian 1 25%
Student > Ph. D. Student 1 25%
Student > Postgraduate 1 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 25%
Social Sciences 1 25%
Medicine and Dentistry 1 25%
Unknown 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2018.
All research outputs
#8,141,128
of 12,980,529 outputs
Outputs from Cell & Bioscience
#114
of 297 outputs
Outputs of similar age
#162,276
of 270,149 outputs
Outputs of similar age from Cell & Bioscience
#1
of 1 outputs
Altmetric has tracked 12,980,529 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 297 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them