Chapter title |
Gaussian Process Inference for Estimating Pharmacokinetic Parameters of Dynamic Contrast-Enhanced MR Images
|
---|---|
Chapter number | 72 |
Book title |
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2012
|
Published in |
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, October 2012
|
DOI | 10.1007/978-3-642-33454-2_72 |
Pubmed ID | |
Book ISBNs |
978-3-64-233453-5, 978-3-64-233454-2
|
Authors |
Wang S, Liu P, Turkbey B, Choyke P, Pinto P, Summers RM, Wang, Shijun, Liu, Peter, Turkbey, Baris, Choyke, Peter, Pinto, Peter, Summers, Ronald M. |
Abstract |
In this paper, we propose a new pharmacokinetic model for parameter estimation of dynamic contrast-enhanced (DCE) MRI by using Gaussian process inference. Our model is based on the Tofts dual-compartment model for the description of tracer kinetics and the observed time series from DCE-MRI is treated as a Gaussian stochastic process. The parameter estimation is done through a maximum likelihood approach and we propose a variant of the coordinate descent method to solve this likelihood maximization problem. The new model was shown to outperform a baseline method on simulated data. Parametric maps generated on prostate DCE data with the new model also provided better enhancement of tumors, lower intensity on false positives, and better boundary delineation when compared with the baseline method. New statistical parameter maps from the process model were also found to be informative, particularly when paired with the PK parameter maps. |
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Demographic breakdown
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Student > Ph. D. Student | 7 | 27% |
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Student > Doctoral Student | 2 | 8% |
Other | 1 | 4% |
Other | 2 | 8% |
Unknown | 3 | 12% |
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Physics and Astronomy | 4 | 15% |
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Other | 1 | 4% |
Unknown | 6 | 23% |