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Prion Proteins

Overview of attention for book
Attention for Chapter 165: Prion Protein and Its Conformational Conversion: A Structural Perspective
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1 tweeter

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69 Mendeley
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Chapter title
Prion Protein and Its Conformational Conversion: A Structural Perspective
Chapter number 165
Book title
Prion Proteins
Published in
Topics in current chemistry, January 2011
DOI 10.1007/128_2011_165
Pubmed ID
Book ISBNs
978-3-64-224066-9, 978-3-64-224067-6
Authors

Witold K. Surewicz, Marcin I. Apostol

Abstract

The key molecular event in the pathogenesis of prion diseases is the conformational conversion of a cellular prion protein, PrP(C), into a misfolded form, PrP(Sc). In contrast to PrP(C) that is monomeric and α-helical, PrP(Sc) is oligomeric in nature and rich in β-sheet structure. According to the "protein-only" model, PrP(Sc) itself represents the infectious prion agent responsible for transmissibility of prion disorders. While this model is supported by rapidly growing experimental data, detailed mechanistic and structural aspects of prion protein conversion remain enigmatic. In this chapter we describe recent advances in understanding biophysical and biochemical aspects of prion diseases, with a special focus on structural underpinnings of prion protein conversion, the structural basis of prion strains, and generation of prion infectivity in vitro from bacterially-expressed recombinant PrP.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
France 1 1%
Lithuania 1 1%
Denmark 1 1%
United States 1 1%
Unknown 64 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 29%
Researcher 17 25%
Student > Bachelor 11 16%
Student > Master 6 9%
Professor > Associate Professor 4 6%
Other 9 13%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 42%
Biochemistry, Genetics and Molecular Biology 16 23%
Chemistry 6 9%
Neuroscience 4 6%
Medicine and Dentistry 4 6%
Other 6 9%
Unknown 4 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2014.
All research outputs
#7,013,044
of 11,285,775 outputs
Outputs from Topics in current chemistry
#65
of 119 outputs
Outputs of similar age
#103,524
of 202,596 outputs
Outputs of similar age from Topics in current chemistry
#6
of 7 outputs
Altmetric has tracked 11,285,775 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 119 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.