Chapter title |
A Two-Week Fecal Microbiota Transplantation Course in Pediatric Patients with Inflammatory Bowel Disease
|
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Chapter number | 123 |
Book title |
Clinical Investigation
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Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_123 |
Pubmed ID | |
Book ISBNs |
978-3-31-974079-9, 978-3-31-974080-5
|
Authors |
Katarzyna Karolewska-Bochenek, Pawel Grzesiowski, Aleksandra Banaszkiewicz, Agnieszka Gawronska, Maria Kotowska, Marcin Dziekiewicz, Piotr Albrecht, Andrzej Radzikowski, Izabella Lazowska-Przeorek, Karolewska-Bochenek, Katarzyna, Grzesiowski, Pawel, Banaszkiewicz, Aleksandra, Gawronska, Agnieszka, Kotowska, Maria, Dziekiewicz, Marcin, Albrecht, Piotr, Radzikowski, Andrzej, Lazowska-Przeorek, Izabella |
Abstract |
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectiveness of a two-week FMT course in children with IBD. Ten patients, 10-17 years of age with moderate to severe IBD received a course of eight doses of freshly prepared FMT via a naso-duodenal tube or gastroscopy. All of the patients had pancolitis. There were eight cases of ulcerative colitis (UC) and two of Crohn's disease (CD). Disease activity was evaluated using the Pediatric UC Activity Index (PUCAI) and Pediatric CD Activity Index (PCDAI) for UC and CD, respectively, CRP, and fecal calprotectin on the day before the first infusion and then on the day before the next course of FMT. Clinical response, defined as a decrease of 15 points in either index, was observed in 9/10 patients (seven UC and two CD). Clinical remission, defined as a PCDAI score ≤ 10 and PUCAI score < 10 measured at the same time point, was observed in 3/8 UC patients and 2/2 CD patients. Side effects observed were self-limiting and benign. We conclude that a short, intensive course of FMT has a beneficial effect on UC and CD colitis. FMT was well-tolerated and safe. Nonetheless, an optimal protocol of FMT administration is crucial for treatment efficacy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 67% |
Greece | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 17% |
Student > Master | 8 | 17% |
Student > Ph. D. Student | 5 | 11% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 6 | 13% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 39% |
Immunology and Microbiology | 5 | 11% |
Nursing and Health Professions | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 13 | 28% |