Chapter title |
ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation
|
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Chapter number | 5 |
Book title |
Chromatin Regulation of Early Embryonic Lineage Specification
|
Published in |
Advances in anatomy embryology and cell biology, January 2018
|
DOI | 10.1007/978-3-319-63187-5_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-963186-8, 978-3-31-963187-5
|
Authors |
Vernadeth B. Alarcon, Yusuke Marikawa, Alarcon, Vernadeth B., Marikawa, Yusuke |
Abstract |
In placental mammalian development, the first cell differentiation produces two distinct lineages that emerge according to their position within the embryo: the trophectoderm (TE, placenta precursor) differentiates in the surface, while the inner cell mass (ICM, fetal body precursor) forms inside. Here, we discuss how such position-dependent lineage specifications are regulated by the RHOA subfamily of small GTPases and RHO-associated coiled-coil kinases (ROCK). Recent studies in mouse show that activities of RHO/ROCK are required to promote TE differentiation and to concomitantly suppress ICM formation. RHO/ROCK operate through the HIPPO signaling pathway, whose cell position-specific modulation is central to establishing unique gene expression profiles that confer cell fate. In particular, activities of RHO/ROCK are essential in outside cells to promote nuclear localization of transcriptional co-activators YAP/TAZ, the downstream effectors of HIPPO signaling. Nuclear localization of YAP/TAZ depends on the formation of apicobasal polarity in outside cells, which requires activities of RHO/ROCK. We propose models of how RHO/ROCK regulate lineage specification and lay out challenges for future investigations to deepen our understanding of the roles of RHO/ROCK in preimplantation development. Finally, as RHO/ROCK may be inhibited by certain pharmacological agents, we discuss their potential impact on human preimplantation development in relation to fertility preservation in women. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 22% |
Professor > Associate Professor | 3 | 13% |
Student > Doctoral Student | 2 | 9% |
Student > Bachelor | 1 | 4% |
Student > Master | 1 | 4% |
Other | 3 | 13% |
Unknown | 8 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 26% |
Agricultural and Biological Sciences | 3 | 13% |
Medicine and Dentistry | 2 | 9% |
Nursing and Health Professions | 1 | 4% |
Chemical Engineering | 1 | 4% |
Other | 2 | 9% |
Unknown | 8 | 35% |