Title |
The future trajectory of adverse outcome pathways: a commentary
|
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Published in |
Archives of Toxicology, March 2018
|
DOI | 10.1007/s00204-018-2183-2 |
Pubmed ID | |
Authors |
Fiona Sewell, Nichola Gellatly, Maria Beaumont, Natalie Burden, Richard Currie, Lolke de Haan, Thomas H. Hutchinson, Miriam Jacobs, Catherine Mahony, Ian Malcomber, Jyotigna Mehta, Graham Whale, Ian Kimber |
Abstract |
The advent of adverse outcome pathways (AOPs) has provided a new lexicon for description of mechanistic toxicology, and a renewed enthusiasm for exploring modes of action resulting in adverse health and environmental effects. In addition, AOPs have been used successfully as a framework for the design and development of non-animal approaches to toxicity testing. Although the value of AOPs is widely recognised, there remain challenges and opportunities associated with their use in practise. The purpose of this article is to consider specifically how the future trajectory of AOPs may provide a basis for addressing some of those challenges and opportunities. |
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Mendeley readers
Geographical breakdown
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