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Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors

Overview of attention for article published in Cell Regeneration, January 2014
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1 tweeter

Citations

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9 Dimensions

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21 Mendeley
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Title
Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors
Published in
Cell Regeneration, January 2014
DOI 10.1186/2045-9769-3-10
Pubmed ID
Authors

Kamesh Narasimhan, Kevin Micoine, Emmanuel Lacôte, Serge Thorimbert, Edwin Cheung, Bernold Hasenknopf, Ralf Jauch

Abstract

SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxometalates as specific SOX transcription factor drugs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 38%
Researcher 3 14%
Student > Bachelor 2 10%
Student > Doctoral Student 2 10%
Professor > Associate Professor 2 10%
Other 2 10%
Unknown 2 10%
Readers by discipline Count As %
Chemistry 8 38%
Biochemistry, Genetics and Molecular Biology 6 29%
Medicine and Dentistry 1 5%
Agricultural and Biological Sciences 1 5%
Unspecified 1 5%
Other 2 10%
Unknown 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2015.
All research outputs
#7,516,068
of 12,018,697 outputs
Outputs from Cell Regeneration
#27
of 37 outputs
Outputs of similar age
#146,965
of 276,993 outputs
Outputs of similar age from Cell Regeneration
#7
of 9 outputs
Altmetric has tracked 12,018,697 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 37 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one scored the same or higher as 10 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,993 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.