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Mendeley readers
Attention Score in Context
| Title |
Biochemical Profiling of Histone Binding Selectivity of the Yeast Bromodomain Family
|
|---|---|
| Published in |
PLOS ONE, January 2010
|
| DOI | 10.1371/journal.pone.0008903 |
| Pubmed ID | |
| Authors |
Qiang Zhang, Suvobrata Chakravarty, Dario Ghersi, Lei Zeng, Alexander N. Plotnikov, Roberto Sanchez, Ming-Ming Zhou |
| Abstract |
It has been shown that molecular interactions between site-specific chemical modifications such as acetylation and methylation on DNA-packing histones and conserved structural modules present in transcriptional proteins are closely associated with chromatin structural changes and gene activation. Unlike methyl-lysine that can interact with different protein modules including chromodomains, Tudor and MBT domains, as well as PHD fingers, acetyl-lysine (Kac) is known thus far to be recognized only by bromodomains. While histone lysine acetylation plays a crucial role in regulation of chromatin-mediated gene transcription, a high degree of sequence variation of the acetyl-lysine binding site in the bromodomains has limited our understanding of histone binding selectivity of the bromodomain family. Here, we report a systematic family-wide analysis of 14 yeast bromodomains binding to 32 lysine-acetylated peptides derived from known major acetylation sites in four core histones that are conserved in eukaryotes. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Switzerland | 1 | 2% |
| France | 1 | 2% |
| United Kingdom | 1 | 2% |
| Canada | 1 | 2% |
| Denmark | 1 | 2% |
| Japan | 1 | 2% |
| Unknown | 50 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 30% |
| Researcher | 11 | 19% |
| Professor | 4 | 7% |
| Student > Bachelor | 3 | 5% |
| Student > Doctoral Student | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 40% |
| Biochemistry, Genetics and Molecular Biology | 14 | 25% |
| Chemistry | 4 | 7% |
| Medicine and Dentistry | 2 | 4% |
| Neuroscience | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 12 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2013.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from PLOS ONE
#88,766
of 194,543 outputs
Outputs of similar age
#48,686
of 164,830 outputs
Outputs of similar age from PLOS ONE
#346
of 637 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,830 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 637 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.