Title |
Hook2 contributes to aggresome formation
|
---|---|
Published in |
BMC Molecular and Cell Biology, May 2007
|
DOI | 10.1186/1471-2121-8-19 |
Pubmed ID | |
Authors |
Györgyi Szebenyi, W Christian Wigley, Branden Hall, Aaron Didier, Michelle Yu, Philip Thomas, Helmut Krämer |
Abstract |
Aggresomes are pericentrosomal accumulations of misfolded proteins, chaperones and proteasomes. Their positioning near the centrosome, like that of other organelles, requires active, microtubule-dependent transport. Linker proteins that can associate with the motor protein dynein, organelles, and microtubules are thought to contribute to the active maintenance of the juxtanuclear localization of many membrane bound organelles and aggresomes. Hook proteins have been proposed to serve as adaptors for the association of cargos with dynein for transport on microtubules. Hook2 was shown to localize to the centrosome, bind centriolin, and contribute to centrosomal function. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 2 | 4% |
Russia | 1 | 2% |
Canada | 1 | 2% |
Unknown | 42 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 26% |
Student > Ph. D. Student | 9 | 20% |
Student > Master | 5 | 11% |
Professor | 2 | 4% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 15% |
Unknown | 9 | 20% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 11 | 24% |
Medicine and Dentistry | 2 | 4% |
Psychology | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Other | 2 | 4% |
Unknown | 9 | 20% |