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A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

Overview of attention for article published in European Journal of Immunology, February 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
90 Dimensions

Readers on

mendeley
80 Mendeley
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Title
A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC
Published in
European Journal of Immunology, February 2009
DOI 10.1002/eji.200839116
Pubmed ID
Authors

Kent S. Boles, William Vermi, Fabio Facchetti, Anja Fuchs, Timothy J. Wilson, Thomas G. Diacovo, Marina Cella, Marco Colonna

Abstract

Nectins and Nectin-like molecules (Necl) play a critical role in cell polarity within epithelia and in the nervous and reproductive systems. Recently, immune receptors specific for Nectins/Necl have been described. Since the expression and distribution of Nectins/Necl is often subverted during tumorigenesis, it has been suggested that the immune system may use these receptors to recognize and eliminate tumors. Here we describe a novel immunoreceptor, Washington University Cell Adhesion Molecule, which is expressed on human follicular B helper T cells (TFH) and binds a Nectin/Necl family member, the poliovirus receptor (PVR), under both static and flow conditions. Furthermore, we demonstrate that PVR is abundantly expressed by follicular DC (FDC) within the germinal center. These results reveal a novel molecular interaction that mediates adhesion of TFH to FDC and provide the first evidence that immune receptors for Nectins/Necl may be involved the generation of T cell-dependent antibody responses.

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
United States 2 3%
Italy 1 1%
Canada 1 1%
Japan 1 1%
United Kingdom 1 1%
Unknown 72 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 24%
Student > Ph. D. Student 19 24%
Student > Master 9 11%
Student > Doctoral Student 6 8%
Student > Bachelor 5 6%
Other 11 14%
Unknown 11 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 38%
Immunology and Microbiology 17 21%
Medicine and Dentistry 13 16%
Biochemistry, Genetics and Molecular Biology 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 1 1%
Unknown 11 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2017.
All research outputs
#2,084,146
of 12,177,809 outputs
Outputs from European Journal of Immunology
#518
of 5,134 outputs
Outputs of similar age
#59,165
of 293,633 outputs
Outputs of similar age from European Journal of Immunology
#3
of 79 outputs
Altmetric has tracked 12,177,809 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,134 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,633 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.