Title |
Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken
|
---|---|
Published in |
BMC Ecology and Evolution, December 2010
|
DOI | 10.1186/1471-2148-10-373 |
Pubmed ID | |
Authors |
Pedro LC Pinheiro, João CR Cardoso, Ana S Gomes, Juan Fuentes, Deborah M Power, Adelino VM Canário |
Abstract |
Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids 1-34) and play key roles in calcium homeostasis, bone formation and skeletal development. Recently, PTH-like peptide (PTH-L) was identified in teleost fish raising questions about the evolution of these proteins. Although PTH and PTHrP have been intensively studied in mammals their function in other vertebrates is poorly documented. Amphibians and birds occupy unique phylogenetic positions, the former at the transition of aquatic to terrestrial life and the latter at the transition to homeothermy. Moreover, both organisms have characteristics indicative of a complex system in calcium regulation. This study investigated PTH family evolution in vertebrates with special emphasis on Xenopus and chicken. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 5% |
Portugal | 2 | 5% |
United Kingdom | 1 | 3% |
Sweden | 1 | 3% |
Unknown | 34 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 23% |
Student > Master | 5 | 13% |
Professor | 4 | 10% |
Student > Bachelor | 4 | 10% |
Student > Ph. D. Student | 4 | 10% |
Other | 11 | 28% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 55% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Medicine and Dentistry | 2 | 5% |
Environmental Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 3 | 8% |
Unknown | 7 | 18% |