Title |
Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae
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Published in |
BMC Ecology and Evolution, May 2011
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DOI | 10.1186/1471-2148-11-123 |
Pubmed ID | |
Authors |
Åke Västermark, Markus Sällman Almén, Martin W Simmen, Robert Fredriksson, Helgi B Schiöth |
Abstract |
The drug/metabolite transporter superfamily comprises a diversity of protein domain families with multiple functions including transport of nucleotide sugars. Drug/metabolite transporter domains are contained in both solute carrier families 30, 35 and 39 proteins as well as in acyl-malonyl condensing enzyme proteins. In this paper, we present an evolutionary analysis of nucleotide sugar transporters in relation to the entire superfamily of drug/metabolite transporters that considers crucial intra-protein duplication events that have shaped the transporters. We use a method that combines the strengths of hidden Markov models and maximum likelihood to find relationships between drug/metabolite transporter families, and branches within families. |
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Demographic breakdown
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