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Mendeley readers
Attention Score in Context
| Title |
Mesenchymal stem cells avoid allogeneic rejection
|
|---|---|
| Published in |
Journal of Inflammation, July 2005
|
| DOI | 10.1186/1476-9255-2-8 |
| Pubmed ID | |
| Authors |
Jennifer M Ryan, Frank P Barry, J Mary Murphy, Bernard P Mahon |
| Abstract |
Adult bone marrow derived mesenchymal stem cells offer the potential to open a new frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of conditions associated with damaged cartilage, bone, muscle, tendon and ligament. However the normal process of immune rejection of mismatched allogeneic tissue would appear to prevent the realisation of such ambitions. In fact mesenchymal stem cells avoid allogeneic rejection in humans and in animal models. These finding are supported by in vitro co-culture studies. Three broad mechanisms contribute to this effect. Firstly, mesenchymal stem cells are hypoimmunogenic, often lacking MHC-II and costimulatory molecule expression. Secondly, these stem cells prevent T cell responses indirectly through modulation of dendritic cells and directly by disrupting NK as well as CD8+ and CD4+ T cell function. Thirdly, mesenchymal stem cells induce a suppressive local microenvironment through the production of prostaglandins and interleukin-10 as well as by the expression of indoleamine 2,3,-dioxygenase, which depletes the local milieu of tryptophan. Comparison is made to maternal tolerance of the fetal allograft, and contrasted with the immune evasion mechanisms of tumor cells. Mesenchymal stem cells are a highly regulated self-renewing population of cells with potent mechanisms to avoid allogeneic rejection. |
Mendeley readers
The data shown below were compiled from readership statistics for 619 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 5 | <1% |
| United States | 5 | <1% |
| Germany | 3 | <1% |
| Ireland | 2 | <1% |
| Italy | 2 | <1% |
| Chile | 2 | <1% |
| United Kingdom | 2 | <1% |
| Iran, Islamic Republic of | 2 | <1% |
| Canada | 2 | <1% |
| Other | 7 | 1% |
| Unknown | 587 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 111 | 18% |
| Researcher | 100 | 16% |
| Student > Master | 96 | 16% |
| Student > Bachelor | 83 | 13% |
| Student > Postgraduate | 33 | 5% |
| Other | 106 | 17% |
| Unknown | 90 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 174 | 28% |
| Medicine and Dentistry | 122 | 20% |
| Biochemistry, Genetics and Molecular Biology | 105 | 17% |
| Engineering | 24 | 4% |
| Immunology and Microbiology | 22 | 4% |
| Other | 64 | 10% |
| Unknown | 108 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2022.
All research outputs
#2,202,259
of 25,374,917 outputs
Outputs from Journal of Inflammation
#16
of 425 outputs
Outputs of similar age
#3,558
of 68,601 outputs
Outputs of similar age from Journal of Inflammation
#1
of 1 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 425 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them