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The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii

Overview of attention for article published in BMC Biology, January 2011
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Title
The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii
Published in
BMC Biology, January 2011
DOI 10.1186/1741-7007-9-7
Pubmed ID
Authors

Nikolaus Pawlowski, Aliaksandr Khaminets, Julia P Hunn, Natasa Papic, Andreas Schmidt, Revathy C Uthaiah, Rita Lange, Gabriela Vopper, Sascha Martens, Eva Wolf, Jonathan C Howard

Abstract

The interferon-inducible immunity-related GTPases (IRG proteins/p47 GTPases) are a distinctive family of GTPases that function as powerful cell-autonomous resistance factors. The IRG protein, Irga6 (IIGP1), participates in the disruption of the vacuolar membrane surrounding the intracellular parasite, Toxoplasma gondii, through which it communicates with its cellular hosts. Some aspects of the protein's behaviour have suggested a dynamin-like molecular mode of action, in that the energy released by GTP hydrolysis is transduced into mechanical work that results in deformation and ultimately rupture of the vacuolar membrane.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 5%
United States 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 25%
Researcher 7 16%
Student > Bachelor 4 9%
Student > Master 4 9%
Professor 4 9%
Other 5 11%
Unknown 9 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 50%
Biochemistry, Genetics and Molecular Biology 6 14%
Immunology and Microbiology 4 9%
Nursing and Health Professions 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 0 0%
Unknown 10 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2011.
All research outputs
#8,784,015
of 25,988,468 outputs
Outputs from BMC Biology
#22
of 30 outputs
Outputs of similar age
#60,294
of 196,509 outputs
Outputs of similar age from BMC Biology
#9
of 12 outputs
Altmetric has tracked 25,988,468 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 30 research outputs from this source. They receive a mean Attention Score of 4.0. This one scored the same or higher as 8 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,509 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.