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Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

Overview of attention for article published in Molecular Cancer, January 2010
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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225 Dimensions

Readers on

mendeley
170 Mendeley
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Title
Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases
Published in
Molecular Cancer, January 2010
DOI 10.1186/1476-4598-9-232
Pubmed ID
Authors

Ravindresh Chhabra, Richa Dubey, Neeru Saini

Abstract

The small RNA molecules of about 19-22 nucleotides in length, aptly called microRNAs, perform the task of gene regulation in the cell. Interestingly, till the early nineties very little was known about them but eventually, the microRNAs have become forefront in the area of research. The huge number of microRNAs plus each one of them targeting a vast number of related as well as unrelated genes makes them very interesting molecules to study. To add to the mystery of miRNAs is the fact that the same miRNA can have antagonizing role in two different cell types i.e. in one cell type; the miRNA promotes proliferation whereas in another cell type the same miRNA inhibits proliferation. Another remarkable aspect of the microRNAs is that many of them exist in clusters. In humans alone, out of 721 microRNAs known, 247 of them occur in 64 clusters at an inter-miRNA distance of less than 5000 bp. The reason for this clustering of miRNAs is not fully understood but since the miRNA clusters are evolutionary conserved, their significance cannot be ruled out. The objective of this review is to summarize the recent progress on the functional characterization of miR-23a~27a~24-2 cluster in humans in relation to various health and diseased conditions and to highlight the cooperative effects of the miRNAs of this cluster.

Mendeley readers

The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 1%
United States 2 1%
Canada 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Russia 1 <1%
Italy 1 <1%
Luxembourg 1 <1%
Unknown 160 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 32%
Researcher 34 20%
Student > Master 24 14%
Student > Doctoral Student 13 8%
Student > Bachelor 12 7%
Other 26 15%
Unknown 6 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 87 51%
Biochemistry, Genetics and Molecular Biology 28 16%
Medicine and Dentistry 24 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Engineering 3 2%
Other 14 8%
Unknown 9 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2011.
All research outputs
#817,639
of 3,627,464 outputs
Outputs from Molecular Cancer
#78
of 438 outputs
Outputs of similar age
#25,153
of 97,182 outputs
Outputs of similar age from Molecular Cancer
#4
of 30 outputs
Altmetric has tracked 3,627,464 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 438 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,182 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.