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PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells

Overview of attention for article published in International Journal of Cell Biology, January 2010
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
21 Mendeley
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Title
PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells
Published in
International Journal of Cell Biology, January 2010
DOI 10.1155/2010/207420
Pubmed ID
Authors

Rivera-Del Valle, Nilsa, Nilsa Rivera-Del Valle, Shan Gao, Claudia P. Miller, Joy Fulbright, Carolina Gonzales, Mint Sirisawad, Susanne Steggerda, Jennifer Wheler, Sriram Balasubramanian, Joya Chandra

Abstract

Histone deacetylase inhibitors (HDACi) have become a promising new avenue for cancer therapy, and many are currently in Phase I/II clinical trials for various tumor types. In the present study, we show that apoptosis induction and histone alterations by PCI-24781, a novel hydroxamic acid-based HDAC inhibitor, require caspase-8 and the adaptor molecule, Fas-associated death domain (FADD), in acute leukemia cells. PCI-24781 treatment also causes an increase in superoxide levels, which has been reported for other HDACi. However, an antioxidant does not reverse histone alterations caused by PCI-24781, indicating that ROS generation is likely downstream of the effects that PCI-24781 exerts on histone H3. Taken together, these results provide insight into the mechanism of apoptosis induction by PCI-24781 in leukemia by highlighting the roles of caspase-8, FADD and increased superoxide levels.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 29%
Student > Master 4 19%
Researcher 3 14%
Professor > Associate Professor 2 10%
Student > Bachelor 1 5%
Other 4 19%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 48%
Chemistry 3 14%
Medicine and Dentistry 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Neuroscience 1 5%
Other 1 5%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2012.
All research outputs
#816,481
of 3,629,479 outputs
Outputs from International Journal of Cell Biology
#10
of 69 outputs
Outputs of similar age
#25,358
of 97,660 outputs
Outputs of similar age from International Journal of Cell Biology
#1
of 1 outputs
Altmetric has tracked 3,629,479 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 69 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,660 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them