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Effects of orally applied Fes p1-displaying L. plantarum WCFS1 on Fes p1 induced allergy in mice

Overview of attention for article published in Journal of Biotechnology, April 2015
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Title
Effects of orally applied Fes p1-displaying L. plantarum WCFS1 on Fes p1 induced allergy in mice
Published in
Journal of Biotechnology, April 2015
DOI 10.1016/j.jbiotec.2015.01.028
Pubmed ID
Authors

Rajna Minic, Marija Gavrovic-Jankulovic, Vladimir Petrusic, Irena Zivkovic, Vincent G.H. Eijsink, Ljiljana Dimitrijevic, Geir Mathiesen

Abstract

Group I grass pollen allergens are major contributors to grass pollen-related seasonal allergic rhinitis, and as such a primary target for allergen specific immunotherapy. In this study the potential therapeutic role of oral application of Lactobacillus plantarum WCFS1, directing cell wall attachment of the recombinant Fes p 1 allergen, from Festuca pratensis was tested in a mouse model of Fes p 1 allergy. For surface expression of Fes p 1 allergen in L. plantarum WCFS1 pSIP system with inducible expression was used. Balb/c mice were sensitized with Fes p 1 protein in alum and subsequently received live recombinant L. plantarum orally. Antibody levels (IgE, total IgG, IgG1, IgG2a, and IgA) were determined by ELISA. Differential eosinophil count in peripheral blood was performed. Reduced peripheral blood eosinophilia and increased serum IgG2A levels was detected in both groups which received live L. plantarum orally. Specific serum IgA levels were increased only in mice treated with the recombinant bacteria. Oral application of L. plantarum WCFS1 has a beneficial therapeutic effect in a mouse model of Fes p 1 allergy. Cell surface expression of Fes p 1 allergen potentiates this phenomenon in an allergen specific way.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 45%
Student > Bachelor 3 10%
Researcher 3 10%
Other 2 6%
Student > Master 2 6%
Other 5 16%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 32%
Immunology and Microbiology 3 10%
Biochemistry, Genetics and Molecular Biology 3 10%
Medicine and Dentistry 3 10%
Nursing and Health Professions 2 6%
Other 8 26%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2015.
All research outputs
#10,845,751
of 12,236,619 outputs
Outputs from Journal of Biotechnology
#2,628
of 2,895 outputs
Outputs of similar age
#190,271
of 229,373 outputs
Outputs of similar age from Journal of Biotechnology
#25
of 39 outputs
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We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.