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Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via apoptosis induction in human breast cancer cells MDA-MB-231

Overview of attention for article published in Cancer Cell International, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#41 of 384)
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
76 Mendeley
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Title
Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via apoptosis induction in human breast cancer cells MDA-MB-231
Published in
Cancer Cell International, January 2009
DOI 10.1186/1475-2867-9-1
Pubmed ID
Authors

Yew Cheah, Fariza Nordin, Rozie Sarip, Thiam Tee, Hawariah Azimahtol, Hasnah M Sirat, Badrul Rashid, Noor Abdullah, Zakiah Ismail

Abstract

It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. The present study was undertaken to evaluate the possibility that the combination of xanthorrhizol and curcumin might show synergistic growth inhibitory effect towards MDA-MB-231 human breast cancer cells via apoptosis induction. The effective dose that produced 50% growth inhibition (GI50) was calculated from the log dose-response curve of fixed-combinations of xanthorrhizol and curcumin generated from the sulforhodamine B (SRB) assay. The experimental GI50 value was used to determine the synergistic activity of the combination treatment by isobolographic analysis and combination-index method. Further investigation of mode of cell death induced by the combination treatment was conducted in the present study.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 1%
Malaysia 1 1%
India 1 1%
Unknown 73 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 29%
Student > Bachelor 12 16%
Researcher 9 12%
Student > Postgraduate 7 9%
Student > Master 7 9%
Other 16 21%
Unknown 3 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 24%
Biochemistry, Genetics and Molecular Biology 13 17%
Medicine and Dentistry 11 14%
Chemistry 10 13%
Pharmacology, Toxicology and Pharmaceutical Science 6 8%
Other 9 12%
Unknown 9 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2015.
All research outputs
#2,174,454
of 9,500,403 outputs
Outputs from Cancer Cell International
#41
of 384 outputs
Outputs of similar age
#57,584
of 217,346 outputs
Outputs of similar age from Cancer Cell International
#1
of 10 outputs
Altmetric has tracked 9,500,403 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 384 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them