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Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

Overview of attention for article published in Genome Biology (Online Edition), February 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
37 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
104 Dimensions

Readers on

mendeley
143 Mendeley
citeulike
5 CiteULike
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Title
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations
Published in
Genome Biology (Online Edition), February 2015
DOI 10.1186/s13059-015-0612-6
Pubmed ID
Authors

Özgün Babur, Mithat Gönen, Bülent Arman Aksoy, Nikolaus Schultz, Giovanni Ciriello, Chris Sander, Emek Demir

Abstract

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.

Twitter Demographics

The data shown below were collected from the profiles of 37 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
Spain 3 2%
Italy 2 1%
Brazil 1 <1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
Belgium 1 <1%
Turkey 1 <1%
Germany 1 <1%
Other 0 0%
Unknown 127 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 42 29%
Student > Ph. D. Student 32 22%
Student > Master 13 9%
Student > Bachelor 12 8%
Student > Doctoral Student 9 6%
Other 23 16%
Unknown 12 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 39%
Biochemistry, Genetics and Molecular Biology 37 26%
Computer Science 19 13%
Engineering 4 3%
Mathematics 4 3%
Other 11 8%
Unknown 12 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2015.
All research outputs
#935,920
of 16,257,022 outputs
Outputs from Genome Biology (Online Edition)
#909
of 3,450 outputs
Outputs of similar age
#15,822
of 218,537 outputs
Outputs of similar age from Genome Biology (Online Edition)
#3
of 7 outputs
Altmetric has tracked 16,257,022 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,450 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.1. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,537 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.