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Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

Overview of attention for article published in Genome Biology, February 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

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34 X users
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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155 Dimensions

Readers on

mendeley
168 Mendeley
citeulike
5 CiteULike
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Title
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations
Published in
Genome Biology, February 2015
DOI 10.1186/s13059-015-0612-6
Pubmed ID
Authors

Özgün Babur, Mithat Gönen, Bülent Arman Aksoy, Nikolaus Schultz, Giovanni Ciriello, Chris Sander, Emek Demir

Abstract

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.

X Demographics

X Demographics

The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
Spain 3 2%
Korea, Republic of 1 <1%
Italy 1 <1%
Turkey 1 <1%
United Kingdom 1 <1%
Germany 1 <1%
Brazil 1 <1%
Belgium 1 <1%
Other 0 0%
Unknown 153 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 45 27%
Student > Ph. D. Student 35 21%
Student > Master 14 8%
Student > Bachelor 13 8%
Student > Doctoral Student 10 6%
Other 28 17%
Unknown 23 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 33%
Biochemistry, Genetics and Molecular Biology 44 26%
Computer Science 20 12%
Medicine and Dentistry 5 3%
Mathematics 4 2%
Other 11 7%
Unknown 28 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2015.
All research outputs
#1,711,447
of 25,374,647 outputs
Outputs from Genome Biology
#1,399
of 4,467 outputs
Outputs of similar age
#21,144
of 270,178 outputs
Outputs of similar age from Genome Biology
#25
of 72 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.