Title |
BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
|
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Published in |
Jornal Brasileiro de Nefrologia, January 2014
|
DOI | 10.5935/0101-2800.20140075 |
Pubmed ID | |
Authors |
Rafael Brandão Varella, Jorge Reis Almeida, Patrícia de Fátima Lopes, Jorge Paulo Strogoff de Matos, Paulo Menezes, Jocemir Ronaldo Lugon |
Abstract |
BK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation. Regular screening for BKPyV reactivation mainly during the first 2 years posttransplant, with subsequent pre-emptive reduction of immunosuppression is considered the best option to avoid disease progression, since successful clearance or reduction of viremia is achieved in the vast majority of patients within 6 months. The use of drugs with antiviral properties for patients with persistent viremia has been attempted despite unclear benefits. Clinical manifestations of BKPyV nephropathy, current strategies for diagnosis and monitoring of BKPyV infection, management of immunosuppressive regimen after detection of BKPyV reactivation and the use of antiviral drugs are discussed in this review. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 18% |
Other | 5 | 13% |
Student > Bachelor | 5 | 13% |
Student > Ph. D. Student | 5 | 13% |
Student > Doctoral Student | 3 | 8% |
Other | 6 | 16% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 39% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Physics and Astronomy | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 4 | 11% |
Unknown | 9 | 24% |