Title |
Syntaxin1A-mediated Resistance and Hypersensitivity to Isoflurane in Drosophila melanogaster
|
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Published in |
Anesthesiology, May 2015
|
DOI | 10.1097/aln.0000000000000629 |
Pubmed ID | |
Authors |
Oressia H. Zalucki, Hareesh Menon, Benjamin Kottler, Richard Faville, Rebecca Day, Adekunle T. Bademosi, Nickolas Lavidis, Shanker Karunanithi, Bruno van Swinderen |
Abstract |
Recent evidence suggests that general anesthetics activate endogenous sleep pathways, yet this mechanism cannot explain the entirety of general anesthesia. General anesthetics could disrupt synaptic release processes, as previous work in Caenorhabditis elegans and in vitro cell preparations suggested a role for the soluble NSF attachment protein receptor protein, syntaxin1A, in mediating resistance to several general anesthetics. The authors questioned whether the syntaxin1A-mediated effects found in these reductionist systems reflected a common anesthetic mechanism distinct from sleep-related processes. |
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Mendeley readers
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